Evidence-Based Psoriasis by Tina Bhutani Wilson Liao & Mio Nakamura

Author:Tina Bhutani, Wilson Liao & Mio Nakamura
Language: eng
Format: epub
Publisher: Springer International Publishing, Cham

Anti-Adalimumab Antibodies

Adalimumab , as with various other biologic agents, can induce the formation of antibodies in vivo. In one multicenter cohort study, 80 patients being treated with adalimumab for psoriasis were followed, with 49% of patients forming anti-adalimumab antibodies [39]. The vast majority of these patients (90%) formed antibodies before week 24. Antibodies to adalimumab are neutralizing antibodies, and so the study authors concluded that the presence of antibodies against adalimumab inversely correlates with adalimumab concentration and clinical response. A systematic review of antidrug antibodies in psoriasis treatment found that antibodies against adalimumab are associated with lower serum adalimumab concentrations and lower PASI-75 response rates [25]. In addition, in rheumatoid arthritis, formation of anti-adalimumab antibodies is associated with lower serum adalimumab levels and significantly fewer treatment responders.

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